Chien Lab

Our lab develops tools for individualized diagnoses, treatment planning, and device evaluation based on computational analysis of patient medical images.

Chien Lab

We are actively seeking collaborations with other researchers and medical professionals. We are recruiting students and postdoctoral fellows from a variety of fields for our cross-disciplinary research.

Chien Lab

We apply computational tools in combination with epidemiological methods to understand the natural history of vascular disease such as hemorrhagic and ischemic stroke.

IVC Filter Analysis

We studied the stability and retrieval of different IVC filters which capture emboli to prevent pulmonary embolisms. The movie clip shows a 3D view of a computer model of an IVC filter and the deformation and force analysis of pulling back the device when attached to the IVC wall.

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IS Flow Map

Blood flow reduction due to flow diverter treatment in patients with brain aneurysms can be measured directly by 2D DSA. This study also verified the impact of input image quality on flow reduction estimation. read more

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Computer simulation for treatment planning

Flow diverters for treating brain aneurysms aim to redirect flow from entering an aneurysm. We have developed 3D computer simulations to analyze the possible flow effects based on patient aneurysm images. The movie shows how flow may change if a Shield Membrane High Coverage (SMHC) flow diverter is implanted. Comparing aneurysm simulations with and without this treatment, the device reduced total flow and lowered peak flow entering the aneurysm.

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Detection of Aneurysm Growth

The risk of treating an unruptured aneurysm needs to be evaluated against the risk of rupture. There are many low risk aneurysms that have been followed over years using imaging to monitor whether risk changes due to growth. We have developed computer programs to help identify aneurysm growth. The movie shows a comparison of the entire brain vascular structure with a patient’s medical images. Left is the vessel images for the initial visit and right is the one year follow up scans and areas of aneurysm growth.

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